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Project B2

Urinary vesicles as signal carriers and markers of kidney function development

Prof. Dr. Hayo Castrop (externer Link, ?ffnet neues Fenster)
Physiology
Universit?t Regensburg

Prof. Dr. Iris Heid (externer Link, ?ffnet neues Fenster)
Genetische Epidemiologie
Universit?t Regensburg

B2 will address three specific aims. We will (i) establish new prognostic biomarkers in urinary vesicles to detect and predict early changes in renal function (vesicular albumin and vesicular podocalyxin), (ii) identify additional tagging proteins in urinary vesicles to gain insights into the types and state of the originating cells, and (iii) clarify the role of extracellular vesicles for intra-renal communication pathways. We will use a broad array of in vivo and in vitro methods and will exploit data from large population-based study groups, taking advantage of the joint expertise on the two PIs in renal (patho-) physiology and epidemiology/statistics, respectively.

Service Project Z1

Kidney imaging and ultrastructure

Prof. Dr. Ralph Witzgall (externer Link, ?ffnet neues Fenster)
Molekulare und Zellul?re Anatomie
Universit?t Regensburg

Prof. Dr. Richard Warth (externer Link, ?ffnet neues Fenster)
Medizinische Zellbiologie
Universtit?t Regensburg

Prof. Dr. Stefan Uderhardt (externer Link, ?ffnet neues Fenster)
Medizinische Klinik 3 - Rheumatologie und Immunologie
Universit?tsklinikum Erlangen

The Z1 service project offers comprehensive, state-of-the-art microscopy techniques and support for kidney imaging . The subprojects are competently supported in the production of high-quality histological images, fluorescence microscopy, confocal microscopy, multiphoton microscopy, lightsheet microscopy, advanced image analysis and 3D reconstructions. Additionally, electron microscopy and correlative confocal/electronic microscopy are offered for ultrastructural analyses.